CMT 3_化工百科

中文名	Incyclinide
英文名	Incyclinide
别名	化合物INCYCLINIDE MMP抑制剂(INCYCLINIDE)
英文别名	COL 3 CMT 3 Metastat NSC 683551 Incyclinide INCYCLINIDE (CMT-3, COL-3) 2-NaphthacenecarboxaMide,1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4aS,5aR,12aS)-
CAS	15866-90-7
化学式	C19H17NO7
分子量	371.34
密度	1.70±0.1 g/cm3(Predicted)
熔点	228-231 °C
沸点	752.8±60.0 °C(Predicted)
溶解度	10毫米DMSO
酸度系数	4.50±1.00(Predicted)
存储条件	-20℃
体外研究	Incyclinide has been shown to experimentally suppress prostate cancer, colon adenocarcinoma and melanoma invasiveness in cell culture. Adding incyclinide at final concentrations of 5 to 20 μM inhibits MT1-MMP gelatinolytic and caseinolytic activity, blocks MT1-MMPactivation of pro-MMP-2, and decreases invasiveness of HT-1080 fibrosarcoma cells. Incyclinide is an especially effective inhibitor of the growth and viability of filamentous fungi. Most of the MICs of CMT-3 against filamentous fungi are found to be between 0.25 and 8 μg/mL, and the inhibition of viability of these fungi by incyclinide is routinely higher than 90%.
体内研究	Incyclinide inhibits tooth movement in the rat, probably by reducing the number of osteoclasts at the compression side. This might be due to induction of apoptosis in activated osteoclasts or reduced osteoclast migration. Reduced MMP activity by incyclinide might also directly inhibit degradation of the organic bone matrix.

CMT 3 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.693 ml	13.465 ml	26.929 ml
5 mM	0.539 ml	2.693 ml	5.386 ml
10 mM	0.269 ml	1.346 ml	2.693 ml
5 mM	0.054 ml	0.269 ml	0.539 ml

最后更新：2024-01-02 23:10:35

上海吉至生化科技有限公司

现货供应

产品名: Incyclinide 去供应商网站查看询盘
CAS: 15866-90-7
产地: 中国上海
包装: 5mg
规格: 95%
价格: 1498.00
库存: 现货
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产品描述: 中文名：Incyclinide 英文名:Incyclinide CAS:15866-90-7 规格:95% 产地:中国上海

上海麦克林生化科技股份有限公司

现货供应

产品名: Incyclinide 去供应商网站查看询盘
CAS: 15866-90-7
产地: 上海
规格: I881909
价格: 1mg-418,5mg-1528,25mg-4585
库存: 现货
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上海源叶生物科技有限公司

产品名: Incyclinide 去供应商网站查看询盘
CAS: 15866-90-7
产地: 上海
规格: 98%
价格: 1mg 1500,5mg 4500,10mg 6500
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